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  <xs:element id="xpo_TradeReceivablesSecuritizationProgramTwoMember" abstract="true" name="TradeReceivablesSecuritizationProgramTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="xpo_AccruedTransportationAndFacilityChargesCurrent" abstract="false" name="AccruedTransportationAndFacilityChargesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="xpo_EuropeanTransportationMember" abstract="true" name="EuropeanTransportationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="xpo_EuropeExcludingFranceAndUnitedKingdomMember" abstract="true" name="EuropeExcludingFranceAndUnitedKingdomMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_RestructuringIncurredCostStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag" abstract="false" name="RestructuringIncurredCostStatementOfIncomeOrComprehensiveIncomeExtensibleEnumerationNotDisclosedFlag" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:booleanItemType"/>
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  <xs:element id="xpo_FinanceLeaseLesseeAbstract" abstract="true" name="FinanceLeaseLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
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  <xs:element id="xpo_CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" abstract="true" name="CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
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  <xs:element id="xpo_OtherLongTermLiabilitiesAndOtherLongTermLiabilitiesMember" abstract="true" name="OtherLongTermLiabilitiesAndOtherLongTermLiabilitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="xpo_NewTermLoanFacilityMember" abstract="true" name="NewTermLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="xpo_A7.125SeniorNotesDue2031Member" abstract="true" name="A7.125SeniorNotesDue2031Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_A7.125SeniorNotesDue2032Member" abstract="true" name="A7.125SeniorNotesDue2032Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_A6.70SeniorDebenturesDue2034Member" abstract="true" name="A6.70SeniorDebenturesDue2034Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="xpo_FinanceLeasesAssetFinancingAndOther" abstract="false" name="FinanceLeasesAssetFinancingAndOther" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_ShortTermDebtAndCurrentMaturitiesOfLongTermDebt" abstract="false" name="ShortTermDebtAndCurrentMaturitiesOfLongTermDebt" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="xpo_ABLFacilityMember" abstract="true" name="ABLFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_CORRAMember" abstract="true" name="CORRAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_UncommittedSecuredLetterOfCreditFacilityMember" abstract="true" name="UncommittedSecuredLetterOfCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="xpo_RefinancingTermLoanB2FacilityMember" abstract="true" name="RefinancingTermLoanB2FacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_RefinancingTermLoanB3FacilityMember" abstract="true" name="RefinancingTermLoanB3FacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_RefinancingTermLoanFacilitiesMember" abstract="true" name="RefinancingTermLoanFacilitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_DebtInstrumentBasisSpreadOnVariableRateDecrease" abstract="false" name="DebtInstrumentBasisSpreadOnVariableRateDecrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="xpo_DebtInstrumentCovenantComplianceLeverageRatioRequired" abstract="false" name="DebtInstrumentCovenantComplianceLeverageRatioRequired" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
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  <xs:element id="xpo_DefinedBenefitPlanNetPeriodicBenefitCostCreditNotYetRecognized" abstract="false" name="DefinedBenefitPlanNetPeriodicBenefitCostCreditNotYetRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="xpo_DefinedBenefitPlanPlanAssetsNetOfLiabilitiesActualAllocationPercentage" abstract="false" name="DefinedBenefitPlanPlanAssetsNetOfLiabilitiesActualAllocationPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="xpo_A2016OmnibusIncentiveCompensationPlanMember" abstract="true" name="A2016OmnibusIncentiveCompensationPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_PerformanceBasedRestrictedStockUnitsMember" abstract="true" name="PerformanceBasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_RestrictedStockUnitsSubjectToServiceandPerformanceConditionsMember" abstract="true" name="RestrictedStockUnitsSubjectToServiceandPerformanceConditionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_PerformancebasedRestrictedStockUnitsSubjectToServiceMarketandPerformanceBasedConditionsMember" abstract="true" name="PerformancebasedRestrictedStockUnitsSubjectToServiceMarketandPerformanceBasedConditionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
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  <xs:element id="xpo_RestrictedStockUnitsandPerformancebasedRestrictedStockUnitsMember" abstract="true" name="RestrictedStockUnitsandPerformancebasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_EmployeeStockPurchasePlanMaximumEmployeeContributionPercent" abstract="false" name="EmployeeStockPurchasePlanMaximumEmployeeContributionPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="xpo_EmployeeStockPurchasePlanDiscountFromMarketRate" abstract="false" name="EmployeeStockPurchasePlanDiscountFromMarketRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="xpo_EmployeeStockPurchasePlanNumberOfSharesAuthorizedForIssuance" abstract="false" name="EmployeeStockPurchasePlanNumberOfSharesAuthorizedForIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
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  <xs:element id="xpo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceAdjustmentWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceAdjustmentWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="xpo_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfPerformanceTargetAwardAchieved" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfPerformanceTargetAwardAchieved" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
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  <xs:element id="xpo_EffectiveIncomeTaxRateReconciliationOtherAdjustmentsLegalEntityReorganizationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationOtherAdjustmentsLegalEntityReorganizationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_EffectiveIncomeTaxRateReconciliationOtherAdjustmentsLegalEntityReorganizationPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationOtherAdjustmentsLegalEntityReorganizationPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="xpo_DeferredTaxLiabilitiesPensionAndOtherRetirementObligations" abstract="false" name="DeferredTaxLiabilitiesPensionAndOtherRetirementObligations" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_UnrecognizedTaxBenefitsAndUnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued" abstract="false" name="UnrecognizedTaxBenefitsAndUnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_InsuranceContributionLitigationMember" abstract="true" name="InsuranceContributionLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_CaliforniaEnvironmentalMattersMember" abstract="true" name="CaliforniaEnvironmentalMattersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_NumberOfInsuranceCompaniesInvolvedInCase" abstract="false" name="NumberOfInsuranceCompaniesInvolvedInCase" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="xpo_NumberOfDefendantInsurers" abstract="false" name="NumberOfDefendantInsurers" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
