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  <xs:element id="xpo_DefiniteLivedIntangiblesAbstract" abstract="true" name="DefiniteLivedIntangiblesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="xpo_NumberOfInsuranceCompaniesInvolvedInCase" abstract="false" name="NumberOfInsuranceCompaniesInvolvedInCase" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="xpo_InsuranceContributionLitigationMember" abstract="true" name="InsuranceContributionLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_UnderwritersMember" abstract="true" name="UnderwritersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_LineofCreditFacilityPrepaymentasPercentageofExcessCashFlow" abstract="false" name="LineofCreditFacilityPrepaymentasPercentageofExcessCashFlow" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="xpo_DebtInstrumentRedemptionAmountReceived" abstract="false" name="DebtInstrumentRedemptionAmountReceived" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_XPOLogisticsEuropeMember" abstract="true" name="XPOLogisticsEuropeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_EmployeeStockPurchasePlanDiscountFromMarketRate" abstract="false" name="EmployeeStockPurchasePlanDiscountFromMarketRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="xpo_NewTermLoanFacilityMember" abstract="true" name="NewTermLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_EffectiveIncomeTaxRateReconciliationLongTermCapitalLoss" abstract="false" name="EffectiveIncomeTaxRateReconciliationLongTermCapitalLoss" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="xpo_FiniteLivedIntangibleAssetUsefulLifeTable" abstract="true" name="FiniteLivedIntangibleAssetUsefulLifeTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="xpo_EffectiveIncomeTaxRateReconciliationContributionAndMarginBasedTaxes" abstract="false" name="EffectiveIncomeTaxRateReconciliationContributionAndMarginBasedTaxes" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="xpo_XPOCollectionsDesignatedActivityCompanyLimitedMember" abstract="true" name="XPOCollectionsDesignatedActivityCompanyLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_WeightedAverageCommonSharesOutstandingAbstract" abstract="true" name="WeightedAverageCommonSharesOutstandingAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="xpo_A2019ProgramMember" abstract="true" name="A2019ProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_A2021ProgramMember" abstract="true" name="A2021ProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_SeniorSecuredNotesDue2028Member" abstract="true" name="SeniorSecuredNotesDue2028Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_PerformanceBasedRestrictedStockUnitsMember" abstract="true" name="PerformanceBasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_XPOMember" abstract="true" name="XPOMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_ShareBasedCompensationArrangementByShareBasedPaymentAwardTermExtensionPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardTermExtensionPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="xpo_LesseeOperatingLeaseLeaseNotYetCommencedUndiscountedAmount" abstract="false" name="LesseeOperatingLeaseLeaseNotYetCommencedUndiscountedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_ABLFacilityMember" abstract="true" name="ABLFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_LineOfCreditFacilityBorrowingBaseMaximumPortionAttributableToEquipmentAndRollingStockPercentage" abstract="false" name="LineOfCreditFacilityBorrowingBaseMaximumPortionAttributableToEquipmentAndRollingStockPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="xpo_BuyOutOfferAndSqueezeOutRemainingPercentage" abstract="false" name="BuyOutOfferAndSqueezeOutRemainingPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="xpo_AdjustmentsToAdditionalPaidInCapitalSpinOff" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalSpinOff" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_ComputerSoftwareMember" abstract="true" name="ComputerSoftwareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="xpo_DebtInstrumentRedemptionPriceAmount" abstract="false" name="DebtInstrumentRedemptionPriceAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
