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  <xs:element id="xpo_XPOCollectionsDesignatedActivityCompanyLimitedMember" abstract="true" name="XPOCollectionsDesignatedActivityCompanyLimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_StockIssuedDuringPeriodSharesExerciseOfWarrants" abstract="false" name="StockIssuedDuringPeriodSharesExerciseOfWarrants" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="xpo_SeniorNotesDue2022Member" abstract="true" name="SeniorNotesDue2022Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_SeparationAndDistributionAgreementsMember" abstract="true" name="SeparationAndDistributionAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_ProceedsRepaymentsFromToLineOfCreditSecuritizationProgram" abstract="false" name="ProceedsRepaymentsFromToLineOfCreditSecuritizationProgram" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_LastMileMember" abstract="true" name="LastMileMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_DisposalGroupIncludingDiscontinuedOperationShortTermOperatingLeaseLiabilitiesCurrent" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationShortTermOperatingLeaseLiabilitiesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_ProceedsFromAccountsReceivableFactoringProgram" abstract="false" name="ProceedsFromAccountsReceivableFactoringProgram" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_TradeReceivablesSecuritizationProgramTwoMember" abstract="true" name="TradeReceivablesSecuritizationProgramTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_AccountsReceivableSoldInFactoringPrograms" abstract="false" name="AccountsReceivableSoldInFactoringPrograms" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_RepaymentsOfLongtermDebtAndFinanceLeases" abstract="false" name="RepaymentsOfLongtermDebtAndFinanceLeases" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_RestrictedStockUnitsSubjectToServiceAndMarketConditionsMember" abstract="true" name="RestrictedStockUnitsSubjectToServiceAndMarketConditionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_ProceedsFromSpinOff" abstract="false" name="ProceedsFromSpinOff" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_StockIssuedDuringPeriodValueSharebasedCompensationExercisedandVested" abstract="false" name="StockIssuedDuringPeriodValueSharebasedCompensationExercisedandVested" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_OtherGeographicalAreasMember" abstract="true" name="OtherGeographicalAreasMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_ArrellanoCaseMember" abstract="true" name="ArrellanoCaseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_EmployeeStockPurchasePlanNumberOfSharesAvailableToBeGranted" abstract="false" name="EmployeeStockPurchasePlanNumberOfSharesAvailableToBeGranted" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="xpo_TermLoanFacilityMember" abstract="true" name="TermLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_UnsecuredCreditFacilityMember" abstract="true" name="UnsecuredCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_TransportationMember" abstract="true" name="TransportationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsVested" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsVested" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="xpo_FairValueOfTransferredCrossCurrencySwaps" abstract="false" name="FairValueOfTransferredCrossCurrencySwaps" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_FinanceLeasesAssetFinancingAndOther" abstract="false" name="FinanceLeasesAssetFinancingAndOther" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_UncommittedSecuredLetterOfCreditFacilityMember" abstract="true" name="UncommittedSecuredLetterOfCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_LesseeOperatingLeaseLeaseNotYetCommencedUndiscountedAmount" abstract="false" name="LesseeOperatingLeaseLeaseNotYetCommencedUndiscountedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_LineOfCreditFacilityBorrowingBaseMaximumPortionAttributableToEquipmentAndRollingStockPercentage" abstract="false" name="LineOfCreditFacilityBorrowingBaseMaximumPortionAttributableToEquipmentAndRollingStockPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="xpo_DefiniteLivedIntangiblesAbstract" abstract="true" name="DefiniteLivedIntangiblesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="xpo_StockholdersEquityNoteSpinoffTransactionRatio" abstract="false" name="StockholdersEquityNoteSpinoffTransactionRatio" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="xpo_EuropeExcludingFranceAndUnitedKingdomMember" abstract="true" name="EuropeExcludingFranceAndUnitedKingdomMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_A2016OmnibusIncentiveCompensationPlanMember" abstract="true" name="A2016OmnibusIncentiveCompensationPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_AdjustedEarningsBeforeInterestTaxesDepreciationAmortization" abstract="false" name="AdjustedEarningsBeforeInterestTaxesDepreciationAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_FiniteLivedIntangibleAssetUsefulLifeLineItems" abstract="true" name="FiniteLivedIntangibleAssetUsefulLifeLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="xpo_StockholdersEquityConversionOfPreferredStock" abstract="false" name="StockholdersEquityConversionOfPreferredStock" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_EffectiveIncomeTaxRateReconciliationForeignOperations" abstract="false" name="EffectiveIncomeTaxRateReconciliationForeignOperations" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="xpo_SeniorNotesDue2024Member" abstract="true" name="SeniorNotesDue2024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_DefinedBenefitPlanPlanAssetsTargetToHedgeProjectedLiabilitiesPercentage" abstract="false" name="DefinedBenefitPlanPlanAssetsTargetToHedgeProjectedLiabilitiesPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="xpo_OperatingLeaseLesseeAbstract" abstract="true" name="OperatingLeaseLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="xpo_UnrecognizedTaxBenefitsAndUnrecognizedTaxBenefitsIncomeTaxPenaltiesandInterestAccrued" abstract="false" name="UnrecognizedTaxBenefitsAndUnrecognizedTaxBenefitsIncomeTaxPenaltiesandInterestAccrued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_FinanceLeaseLesseeAbstract" abstract="true" name="FinanceLeaseLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="xpo_EffectiveIncomeTaxRateReconciliationContributionAndMarginBasedTaxes" abstract="false" name="EffectiveIncomeTaxRateReconciliationContributionAndMarginBasedTaxes" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="xpo_OtherComprehensiveIncomeLossForeignCurrencyOptionAndForwardContractsGainLossAfterReclassificationAndTax" abstract="false" name="OtherComprehensiveIncomeLossForeignCurrencyOptionAndForwardContractsGainLossAfterReclassificationAndTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_A2021ProgramMember" abstract="true" name="A2021ProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_LesseeScheduleOfBalanceSheetInformationForOperatingAndFinancingLeasesTableTextBlock" abstract="false" name="LesseeScheduleOfBalanceSheetInformationForOperatingAndFinancingLeasesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="xpo_StockholdersEquityLineItems" abstract="true" name="StockholdersEquityLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="xpo_StockIssuedDuringPeriodSharesSharebasedCompensationExercisedandVested" abstract="false" name="StockIssuedDuringPeriodSharesSharebasedCompensationExercisedandVested" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="xpo_EmployeeStockPurchasePlanDiscountFromMarketRate" abstract="false" name="EmployeeStockPurchasePlanDiscountFromMarketRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="xpo_A2020ProgramMember" abstract="true" name="A2020ProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_AccruedTransportationAndFacilityChargesCurrent" abstract="false" name="AccruedTransportationAndFacilityChargesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_IncrementalLoanFacilityMember" abstract="true" name="IncrementalLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_NetInvestmentHedgeMember" abstract="true" name="NetInvestmentHedgeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_QuarterlyFinancialInformationTable" abstract="true" name="QuarterlyFinancialInformationTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="xpo_ScheduleOfAccountsReceivableSecuritizationAndFactoringProgramsTableTextBlock" abstract="false" name="ScheduleOfAccountsReceivableSecuritizationAndFactoringProgramsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="xpo_AdoptionOfNewAccountingStandardAndOtherShares" abstract="false" name="AdoptionOfNewAccountingStandardAndOtherShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="xpo_ShortTermDebtAndMaturitiesOfLongTermDebtCurrent" abstract="false" name="ShortTermDebtAndMaturitiesOfLongTermDebtCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_DisposalGroupIncludingDiscontinuedOperationLongTermOperatingLeaseLiabilitiesNoncurrent" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationLongTermOperatingLeaseLiabilitiesNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_DeferredTaxLiabilitiesPensionAndOtherRetirementObligations" abstract="false" name="DeferredTaxLiabilitiesPensionAndOtherRetirementObligations" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_FinanceLeaseCostTotal" abstract="false" name="FinanceLeaseCostTotal" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xpo_PreferredStockIssuedDuringPeriodSharesNewShares" abstract="false" name="PreferredStockIssuedDuringPeriodSharesNewShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="xpo_FixedChargeCoverageRatio" abstract="false" name="FixedChargeCoverageRatio" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="xpo_NorthAmericaExcludingUnitedStatesMember" abstract="true" name="NorthAmericaExcludingUnitedStatesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xpo_GXOMember" abstract="true" name="GXOMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
