<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.xpologistics.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:href="xpo-20170930.xsd#CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/CondensedConsolidatedBalanceSheetsUnauditedParenthetical" xlink:href="xpo-20170930.xsd#CondensedConsolidatedBalanceSheetsUnauditedParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:href="xpo-20170930.xsd#CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeLossUnaudited" xlink:href="xpo-20170930.xsd#CondensedConsolidatedStatementsOfComprehensiveIncomeLossUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeLossUnauditedParenthetical" xlink:href="xpo-20170930.xsd#CondensedConsolidatedStatementsOfComprehensiveIncomeLossUnauditedParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/CondensedConsolidatedStatementsOfOperationsUnaudited" xlink:href="xpo-20170930.xsd#CondensedConsolidatedStatementsOfOperationsUnaudited" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/Debt" xlink:href="xpo-20170930.xsd#Debt" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/DebtAdditionalInformationDetails" xlink:href="xpo-20170930.xsd#DebtAdditionalInformationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/DebtScheduleOfLongTermDebtDetails" xlink:href="xpo-20170930.xsd#DebtScheduleOfLongTermDebtDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/DebtTables" xlink:href="xpo-20170930.xsd#DebtTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/DerivativeInstruments" xlink:href="xpo-20170930.xsd#DerivativeInstruments" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/DerivativeInstrumentsNarrativeDetails" xlink:href="xpo-20170930.xsd#DerivativeInstrumentsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/DerivativeInstrumentsScheduleOfDerivativeInstrumentsMeasuredAtFairValueInStatementOfFinancialPositionDetails" xlink:href="xpo-20170930.xsd#DerivativeInstrumentsScheduleOfDerivativeInstrumentsMeasuredAtFairValueInStatementOfFinancialPositionDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/DerivativeInstrumentsScheduleOfGainsAndLossesRecognizedOnBalanceSheetForDerivativeInstrumentsDetails" xlink:href="xpo-20170930.xsd#DerivativeInstrumentsScheduleOfGainsAndLossesRecognizedOnBalanceSheetForDerivativeInstrumentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/DerivativeInstrumentsTables" xlink:href="xpo-20170930.xsd#DerivativeInstrumentsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/DocumentAndEntityInformation" xlink:href="xpo-20170930.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/EarningsPerShare" xlink:href="xpo-20170930.xsd#EarningsPerShare" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/EarningsPerShareScheduleOfEarningsPerShareDetails" xlink:href="xpo-20170930.xsd#EarningsPerShareScheduleOfEarningsPerShareDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/EarningsPerShareTables" xlink:href="xpo-20170930.xsd#EarningsPerShareTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/FairValueMeasurements" xlink:href="xpo-20170930.xsd#FairValueMeasurements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/LegalAndRegulatoryMatters" xlink:href="xpo-20170930.xsd#LegalAndRegulatoryMatters" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/LegalAndRegulatoryMattersAdditionalInformationDetails" xlink:href="xpo-20170930.xsd#LegalAndRegulatoryMattersAdditionalInformationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/OrganizationDescriptionOfBusinessAndBasisOfPresentation" xlink:href="xpo-20170930.xsd#OrganizationDescriptionOfBusinessAndBasisOfPresentation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/OrganizationDescriptionOfBusinessAndBasisOfPresentationAdditionalInformationDetails" xlink:href="xpo-20170930.xsd#OrganizationDescriptionOfBusinessAndBasisOfPresentationAdditionalInformationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/OrganizationDescriptionOfBusinessAndBasisOfPresentationPolicies" xlink:href="xpo-20170930.xsd#OrganizationDescriptionOfBusinessAndBasisOfPresentationPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/RestructuringCharges" xlink:href="xpo-20170930.xsd#RestructuringCharges" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/RestructuringChargesSummaryOfRestructuringReserveDetails" xlink:href="xpo-20170930.xsd#RestructuringChargesSummaryOfRestructuringReserveDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/RestructuringChargesTables" xlink:href="xpo-20170930.xsd#RestructuringChargesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/SegmentReporting" xlink:href="xpo-20170930.xsd#SegmentReporting" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/SegmentReportingAdditionalInformationDetails" xlink:href="xpo-20170930.xsd#SegmentReportingAdditionalInformationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/SegmentReportingSelectedFinancialDataForEachOfOperatingSegmentsDetails" xlink:href="xpo-20170930.xsd#SegmentReportingSelectedFinancialDataForEachOfOperatingSegmentsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/SegmentReportingTables" xlink:href="xpo-20170930.xsd#SegmentReportingTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/StockholdersEquity" xlink:href="xpo-20170930.xsd#StockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/StockholdersEquityDetails" xlink:href="xpo-20170930.xsd#StockholdersEquityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/SubsequentEvents" xlink:href="xpo-20170930.xsd#SubsequentEvents" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xpologistics.com/role/SubsequentEventsDetails" xlink:href="xpo-20170930.xsd#SubsequentEventsDetails" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple" />
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/CondensedConsolidatedBalanceSheetsUnaudited" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/CondensedConsolidatedBalanceSheetsUnauditedParenthetical" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/CondensedConsolidatedStatementsOfCashFlowsUnaudited" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeLossUnaudited" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/CondensedConsolidatedStatementsOfComprehensiveIncomeLossUnauditedParenthetical" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/CondensedConsolidatedStatementsOfOperationsUnaudited" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/Debt" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/DebtAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_6E3D311614D33524DD2C8D065B3B33BC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_us-gaap_DebtInstrumentTable_6E3D311614D33524DD2C8D065B3B33BC" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_B1C68795D9991FE203198D065B3B94C7" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_6E3D311614D33524DD2C8D065B3B33BC" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_B1C68795D9991FE203198D065B3B94C7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_C6FC7268DDE1A3A8761A8D065B3BB86F_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_B1C68795D9991FE203198D065B3B94C7" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_C6FC7268DDE1A3A8761A8D065B3BB86F_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_C6FC7268DDE1A3A8761A8D065B3BB86F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_B1C68795D9991FE203198D065B3B94C7" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_C6FC7268DDE1A3A8761A8D065B3BB86F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtMember" xlink:label="loc_us-gaap_LongTermDebtMember_CA90380FEFE68CCB1BC88D065B3B0055" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_C6FC7268DDE1A3A8761A8D065B3BB86F" xlink:to="loc_us-gaap_LongTermDebtMember_CA90380FEFE68CCB1BC88D065B3B0055" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EquityMember" xlink:label="loc_us-gaap_EquityMember_8140EB1F584AA780FDB78D065B3B8DDE" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_C6FC7268DDE1A3A8761A8D065B3BB86F" xlink:to="loc_us-gaap_EquityMember_8140EB1F584AA780FDB78D065B3B8DDE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_47DD2809B77A178D1E108D065B3B054B" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_6E3D311614D33524DD2C8D065B3B33BC" xlink:to="loc_us-gaap_RangeAxis_47DD2809B77A178D1E108D065B3B054B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_3327D3630F711416FF9E8D065B3BCEF3_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_47DD2809B77A178D1E108D065B3B054B" xlink:to="loc_us-gaap_RangeMember_3327D3630F711416FF9E8D065B3BCEF3_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_3327D3630F711416FF9E8D065B3BCEF3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_47DD2809B77A178D1E108D065B3B054B" xlink:to="loc_us-gaap_RangeMember_3327D3630F711416FF9E8D065B3BCEF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_DD2151DA8015E979ADDF8D065B3BDDD1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_3327D3630F711416FF9E8D065B3BCEF3" xlink:to="loc_us-gaap_MaximumMember_DD2151DA8015E979ADDF8D065B3BDDD1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_C4C0C5682B966F1F57038D065B3B1B81" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_3327D3630F711416FF9E8D065B3BCEF3" xlink:to="loc_us-gaap_MinimumMember_C4C0C5682B966F1F57038D065B3B1B81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityAxis" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_B0E0274108375F83A1E28D065B3BE16B" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_6E3D311614D33524DD2C8D065B3B33BC" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_B0E0274108375F83A1E28D065B3BE16B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_92D840326A44F43A3F488D065B3B14F0_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_B0E0274108375F83A1E28D065B3BE16B" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_92D840326A44F43A3F488D065B3B14F0_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LineOfCreditFacilityLenderDomain" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_92D840326A44F43A3F488D065B3B14F0" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_B0E0274108375F83A1E28D065B3BE16B" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_92D840326A44F43A3F488D065B3B14F0" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_MorganStanleySeniorFundingInc.Member" xlink:label="loc_xpo_MorganStanleySeniorFundingInc.Member_099F45E2BBDBC18CC2D58D065B3B9211" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_92D840326A44F43A3F488D065B3B14F0" xlink:to="loc_xpo_MorganStanleySeniorFundingInc.Member_099F45E2BBDBC18CC2D58D065B3B9211" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_9162CDFF5279A15F35ED8D065B3CB110" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_6E3D311614D33524DD2C8D065B3B33BC" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_9162CDFF5279A15F35ED8D065B3CB110" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_0184ADBD2B35CBF27F7B8D065B3C9918_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_9162CDFF5279A15F35ED8D065B3CB110" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_0184ADBD2B35CBF27F7B8D065B3C9918_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_0184ADBD2B35CBF27F7B8D065B3C9918" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_9162CDFF5279A15F35ED8D065B3CB110" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_0184ADBD2B35CBF27F7B8D065B3C9918" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SecuredDebtMember" xlink:label="loc_us-gaap_SecuredDebtMember_F4D5532D89D96DA703A48D065B3C84FC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_0184ADBD2B35CBF27F7B8D065B3C9918" xlink:to="loc_us-gaap_SecuredDebtMember_F4D5532D89D96DA703A48D065B3C84FC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_F88BE98E4860C7D7AB628D065B3C017F" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_6E3D311614D33524DD2C8D065B3B33BC" xlink:to="loc_us-gaap_DebtInstrumentAxis_F88BE98E4860C7D7AB628D065B3C017F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_296848B9E14A370234BD8D065B3CE4F6_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_F88BE98E4860C7D7AB628D065B3C017F" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_296848B9E14A370234BD8D065B3CE4F6_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_296848B9E14A370234BD8D065B3CE4F6" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_F88BE98E4860C7D7AB628D065B3C017F" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_296848B9E14A370234BD8D065B3CE4F6" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_AmendmentNo.1toCreditAgreementMember" xlink:label="loc_xpo_AmendmentNo.1toCreditAgreementMember_8A3356A4E4BCF3156C238D065B3CA10D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_296848B9E14A370234BD8D065B3CE4F6" xlink:to="loc_xpo_AmendmentNo.1toCreditAgreementMember_8A3356A4E4BCF3156C238D065B3CA10D" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_AmendmentNo.2toCreditAgreementMember" xlink:label="loc_xpo_AmendmentNo.2toCreditAgreementMember_9916D22F50401A1C7F058D065B3C4DCB" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_296848B9E14A370234BD8D065B3CE4F6" xlink:to="loc_xpo_AmendmentNo.2toCreditAgreementMember_9916D22F50401A1C7F058D065B3C4DCB" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_TermLoanFacilityMember" xlink:label="loc_xpo_TermLoanFacilityMember_D0D4791BE11E34D2CE818D065B3CEBD6" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_296848B9E14A370234BD8D065B3CE4F6" xlink:to="loc_xpo_TermLoanFacilityMember_D0D4791BE11E34D2CE818D065B3CEBD6" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_SeniorNotesDue2018Member" xlink:label="loc_xpo_SeniorNotesDue2018Member_954047816E5EBA4094E68D065B3CE1BC" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_296848B9E14A370234BD8D065B3CE4F6" xlink:to="loc_xpo_SeniorNotesDue2018Member_954047816E5EBA4094E68D065B3CE1BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_1EEA748092F346A2F4CC8D065B3C3D7B" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_6E3D311614D33524DD2C8D065B3B33BC" xlink:to="loc_us-gaap_VariableRateAxis_1EEA748092F346A2F4CC8D065B3C3D7B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_5850FF44A6406A1FE4A38D065B3C6F40_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_1EEA748092F346A2F4CC8D065B3C3D7B" xlink:to="loc_us-gaap_VariableRateDomain_5850FF44A6406A1FE4A38D065B3C6F40_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_5850FF44A6406A1FE4A38D065B3C6F40" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_1EEA748092F346A2F4CC8D065B3C3D7B" xlink:to="loc_us-gaap_VariableRateDomain_5850FF44A6406A1FE4A38D065B3C6F40" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BaseRateMember" xlink:label="loc_us-gaap_BaseRateMember_D368BEEDB25BC4AF7B478D065B3CF8F5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_5850FF44A6406A1FE4A38D065B3C6F40" xlink:to="loc_us-gaap_BaseRateMember_D368BEEDB25BC4AF7B478D065B3CF8F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_0681954C9729414FA4BA8D065B3C86C1" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_5850FF44A6406A1FE4A38D065B3C6F40" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_0681954C9729414FA4BA8D065B3C86C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_93FDC2AB93DA1B02515F8D065B3C5684" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_us-gaap_LongTermDebt_93FDC2AB93DA1B02515F8D065B3C5684" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_ProceedsFromIssuanceOfLongTermDebtForGeneralCorporatePurposes" xlink:label="loc_xpo_ProceedsFromIssuanceOfLongTermDebtForGeneralCorporatePurposes_8D5A42B4171444A00A2B8D065B3C5600" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_xpo_ProceedsFromIssuanceOfLongTermDebtForGeneralCorporatePurposes_8D5A42B4171444A00A2B8D065B3C5600" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_BC8913EE1EC3534872C38D065B3CEF2C" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_BC8913EE1EC3534872C38D065B3CEF2C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_55C668AE511EF39922448D065B3CD778" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_55C668AE511EF39922448D065B3CD778" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_EBA2D28B64E01EA76D948D065B3CB511" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_EBA2D28B64E01EA76D948D065B3CB511" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_0EE05D19F09B47609E358D065B3C5717" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_0EE05D19F09B47609E358D065B3C5717" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentRedemptionPricePercentage" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_8203BCC2271B6EBB26678D065B3C62C6" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPricePercentage_8203BCC2271B6EBB26678D065B3C62C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_FFDA2F8453C71C91DA468D065B3D9C7A" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_FFDA2F8453C71C91DA468D065B3D9C7A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_2F99C5BE0F06B9CD4B688D065B3D7BCA" xlink:type="locator" />
    <link:definitionArc order="9" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_2F99C5BE0F06B9CD4B688D065B3D7BCA" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_GainLossOnConversionOfDebt" xlink:label="loc_xpo_GainLossOnConversionOfDebt_3E18E80A760E5C1E546B8D065B3DE70E" xlink:type="locator" />
    <link:definitionArc order="10" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_4F18B8B75FDD96AD34128D065B3C49E1" xlink:to="loc_xpo_GainLossOnConversionOfDebt_3E18E80A760E5C1E546B8D065B3DE70E" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/DebtScheduleOfLongTermDebtDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_C04FBDCC7B215250590039D5CC41FEC5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_99A108808F6FEFB9DDD539D5CC3F1598" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_C04FBDCC7B215250590039D5CC41FEC5" xlink:to="loc_us-gaap_DebtInstrumentTable_99A108808F6FEFB9DDD539D5CC3F1598" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_0ACEC8A2F3368191A3E239D5CC3F1EFC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_99A108808F6FEFB9DDD539D5CC3F1598" xlink:to="loc_us-gaap_CreditFacilityAxis_0ACEC8A2F3368191A3E239D5CC3F1EFC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_AA5901E893A69F53158839D5CC407D8F_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_0ACEC8A2F3368191A3E239D5CC3F1EFC" xlink:to="loc_us-gaap_CreditFacilityDomain_AA5901E893A69F53158839D5CC407D8F_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_AA5901E893A69F53158839D5CC407D8F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_0ACEC8A2F3368191A3E239D5CC3F1EFC" xlink:to="loc_us-gaap_CreditFacilityDomain_AA5901E893A69F53158839D5CC407D8F" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_ABLFacilityMember" xlink:label="loc_xpo_ABLFacilityMember_AA5D04AE201C635634DE39D5CC40C070" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_AA5901E893A69F53158839D5CC407D8F" xlink:to="loc_xpo_ABLFacilityMember_AA5D04AE201C635634DE39D5CC40C070" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_F137B3571114E5CF453639D5CC40E212" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_99A108808F6FEFB9DDD539D5CC3F1598" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_F137B3571114E5CF453639D5CC40E212" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9BB5081219AA81EFCEB739D5CC40D21D_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_F137B3571114E5CF453639D5CC40E212" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9BB5081219AA81EFCEB739D5CC40D21D_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_DE0AC3DD2D80E16014F439D5CC407715" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_F137B3571114E5CF453639D5CC40E212" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_DE0AC3DD2D80E16014F439D5CC407715" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9BB5081219AA81EFCEB739D5CC40D21D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_DE0AC3DD2D80E16014F439D5CC407715" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9BB5081219AA81EFCEB739D5CC40D21D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_ACE07CE53383CCD1987E39D5CC4014A1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9BB5081219AA81EFCEB739D5CC40D21D" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_ACE07CE53383CCD1987E39D5CC4014A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_D4F3D284DEE865FE771339D5CC40CF17" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_99A108808F6FEFB9DDD539D5CC3F1598" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_D4F3D284DEE865FE771339D5CC40CF17" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5CB5830AD813716654EA39D5CC402DC8_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_D4F3D284DEE865FE771339D5CC40CF17" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5CB5830AD813716654EA39D5CC402DC8_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5CB5830AD813716654EA39D5CC402DC8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_D4F3D284DEE865FE771339D5CC40CF17" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5CB5830AD813716654EA39D5CC402DC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_3E0FA7B659A11D63C2D739D5CC404537" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5CB5830AD813716654EA39D5CC402DC8" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_3E0FA7B659A11D63C2D739D5CC404537" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_15C6B1B4FAC2B6F45DB639D5CC40ACD4" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_5CB5830AD813716654EA39D5CC402DC8" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_15C6B1B4FAC2B6F45DB639D5CC40ACD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_60BD23A646D75FB014B439D5CC402BC4" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_99A108808F6FEFB9DDD539D5CC3F1598" xlink:to="loc_us-gaap_DebtInstrumentAxis_60BD23A646D75FB014B439D5CC402BC4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_60BD23A646D75FB014B439D5CC402BC4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_60BD23A646D75FB014B439D5CC402BC4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_SeniorNotesDue2023Member" xlink:label="loc_xpo_SeniorNotesDue2023Member_E0642FC1934DA12BF28839D5CC40989B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:to="loc_xpo_SeniorNotesDue2023Member_E0642FC1934DA12BF28839D5CC40989B" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_SeniorNotesDue2022Member" xlink:label="loc_xpo_SeniorNotesDue2022Member_8886FF253C2DC05C167F39D5CC404DCE" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:to="loc_xpo_SeniorNotesDue2022Member_8886FF253C2DC05C167F39D5CC404DCE" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_SeniorNotesDue2021Member" xlink:label="loc_xpo_SeniorNotesDue2021Member_3DFD537A4EB173CB531839D5CC40AA1F" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:to="loc_xpo_SeniorNotesDue2021Member_3DFD537A4EB173CB531839D5CC40AA1F" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_SeniorNotesDue2018Member" xlink:label="loc_xpo_SeniorNotesDue2018Member_0935090B4779FBBE4EB339D5CC409862" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:to="loc_xpo_SeniorNotesDue2018Member_0935090B4779FBBE4EB339D5CC409862" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_TermLoanFacilityMember" xlink:label="loc_xpo_TermLoanFacilityMember_A5E2546EE18D4C4FDCA539D5CC400326" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:to="loc_xpo_TermLoanFacilityMember_A5E2546EE18D4C4FDCA539D5CC400326" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_SeniorDebenturesDue2034Member" xlink:label="loc_xpo_SeniorDebenturesDue2034Member_92023E2458B9BBD1402839D5CC4013A4" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:to="loc_xpo_SeniorDebenturesDue2034Member_92023E2458B9BBD1402839D5CC4013A4" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_EuroPrivatePlacementNotesdue2020Member" xlink:label="loc_xpo_EuroPrivatePlacementNotesdue2020Member_18FFFFF446F625201BAD39D5CC405244" xlink:type="locator" />
    <link:definitionArc order="7" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:to="loc_xpo_EuroPrivatePlacementNotesdue2020Member_18FFFFF446F625201BAD39D5CC405244" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_AssetFinanceDebtMember" xlink:label="loc_xpo_AssetFinanceDebtMember_AEA17276BE731FE4398B39D5CC4053C1" xlink:type="locator" />
    <link:definitionArc order="8" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_F8540E697D3BDD37F3AE39D5CC40E069" xlink:to="loc_xpo_AssetFinanceDebtMember_AEA17276BE731FE4398B39D5CC4053C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_4DA69B806F9D5E118E3739D5CC41C312" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_99A108808F6FEFB9DDD539D5CC3F1598" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_4DA69B806F9D5E118E3739D5CC41C312" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_3312E91B1450C8AC13DF39D5CC41F91E_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_4DA69B806F9D5E118E3739D5CC41C312" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_3312E91B1450C8AC13DF39D5CC41F91E_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_3312E91B1450C8AC13DF39D5CC41F91E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_4DA69B806F9D5E118E3739D5CC41C312" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_3312E91B1450C8AC13DF39D5CC41F91E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConvertibleDebtMember" xlink:label="loc_us-gaap_ConvertibleDebtMember_82A27A4F54F1707B4BEC39D5CC417846" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_3312E91B1450C8AC13DF39D5CC41F91E" xlink:to="loc_us-gaap_ConvertibleDebtMember_82A27A4F54F1707B4BEC39D5CC417846" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CapitalLeaseObligationsMember" xlink:label="loc_us-gaap_CapitalLeaseObligationsMember_7583B8F59FF43EA04A2439D5CC413A80" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_3312E91B1450C8AC13DF39D5CC41F91E" xlink:to="loc_us-gaap_CapitalLeaseObligationsMember_7583B8F59FF43EA04A2439D5CC413A80" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_8121586EFABDB984A83639D5CC417F1C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_C04FBDCC7B215250590039D5CC41FEC5" xlink:to="loc_us-gaap_LongTermDebt_8121586EFABDB984A83639D5CC417F1C" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_LongtermDebtGrossCurrentMaturities" xlink:label="loc_xpo_LongtermDebtGrossCurrentMaturities_FE93EF4824C72CB185EB39D5CC419D86" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_C04FBDCC7B215250590039D5CC41FEC5" xlink:to="loc_xpo_LongtermDebtGrossCurrentMaturities_FE93EF4824C72CB185EB39D5CC419D86" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_94B22A1C4BC3B200D17839D5CC41621D" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_C04FBDCC7B215250590039D5CC41FEC5" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_94B22A1C4BC3B200D17839D5CC41621D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtFairValue" xlink:label="loc_us-gaap_LongTermDebtFairValue_D8E5C03AD894E7BB214E39D5CC41DBEC" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_C04FBDCC7B215250590039D5CC41FEC5" xlink:to="loc_us-gaap_LongTermDebtFairValue_D8E5C03AD894E7BB214E39D5CC41DBEC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_E415F562187159BE8DEB39D5CC41875E" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_C04FBDCC7B215250590039D5CC41FEC5" xlink:to="loc_us-gaap_LongTermDebtCurrent_E415F562187159BE8DEB39D5CC41875E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_360C95F1614569459C5439D5CC419B5D" xlink:type="locator" />
    <link:definitionArc order="6" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_C04FBDCC7B215250590039D5CC41FEC5" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_360C95F1614569459C5439D5CC419B5D" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/DebtTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/DerivativeInstruments" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/DerivativeInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_C871059F766999439F16EDE7D031147E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_82D0F2596E4060710A5CEDE7D02B25C3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_C871059F766999439F16EDE7D031147E" xlink:to="loc_us-gaap_DerivativeTable_82D0F2596E4060710A5CEDE7D02B25C3" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_BBFD38AD74C078597EBDEDE7D02FE4CE" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_82D0F2596E4060710A5CEDE7D02B25C3" xlink:to="loc_us-gaap_RangeAxis_BBFD38AD74C078597EBDEDE7D02FE4CE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_F07EF41E9DD89DF98965EDE7D02F09F4_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RangeAxis_BBFD38AD74C078597EBDEDE7D02FE4CE" xlink:to="loc_us-gaap_RangeMember_F07EF41E9DD89DF98965EDE7D02F09F4_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_F07EF41E9DD89DF98965EDE7D02F09F4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RangeAxis_BBFD38AD74C078597EBDEDE7D02FE4CE" xlink:to="loc_us-gaap_RangeMember_F07EF41E9DD89DF98965EDE7D02F09F4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_DA179F9335111B8B10FFEDE7D030F9A1" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RangeMember_F07EF41E9DD89DF98965EDE7D02F09F4" xlink:to="loc_us-gaap_MaximumMember_DA179F9335111B8B10FFEDE7D030F9A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_7986BB50ECDFA490FA39EDE7D0305FE4" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_82D0F2596E4060710A5CEDE7D02B25C3" xlink:to="loc_us-gaap_HedgingDesignationAxis_7986BB50ECDFA490FA39EDE7D0305FE4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_9C16C4BD97858974BB66EDE7D030E49F_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_7986BB50ECDFA490FA39EDE7D0305FE4" xlink:to="loc_us-gaap_HedgingDesignationDomain_9C16C4BD97858974BB66EDE7D030E49F_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_9C16C4BD97858974BB66EDE7D030E49F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_7986BB50ECDFA490FA39EDE7D0305FE4" xlink:to="loc_us-gaap_HedgingDesignationDomain_9C16C4BD97858974BB66EDE7D030E49F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_E6D646BB51A7D9837EBCEDE7D030D2D2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_9C16C4BD97858974BB66EDE7D030E49F" xlink:to="loc_us-gaap_NondesignatedMember_E6D646BB51A7D9837EBCEDE7D030D2D2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_CF1EBAB00E386C55F7F9EDE7D0313935" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_82D0F2596E4060710A5CEDE7D02B25C3" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_CF1EBAB00E386C55F7F9EDE7D0313935" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_F0EF39BAE59C6079B2CAEDE7D0317C90_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_CF1EBAB00E386C55F7F9EDE7D0313935" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_F0EF39BAE59C6079B2CAEDE7D0317C90_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_F0EF39BAE59C6079B2CAEDE7D0317C90" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_CF1EBAB00E386C55F7F9EDE7D0313935" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_F0EF39BAE59C6079B2CAEDE7D0317C90" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ForeignExchangeForwardMember" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_67464DE3528267478C33EDE7D031C676" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_F0EF39BAE59C6079B2CAEDE7D0317C90" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_67464DE3528267478C33EDE7D031C676" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeTermOfContract" xlink:label="loc_us-gaap_DerivativeTermOfContract_B97EB391D17B8460399AEDE7D031895C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_C871059F766999439F16EDE7D031147E" xlink:to="loc_us-gaap_DerivativeTermOfContract_B97EB391D17B8460399AEDE7D031895C" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/DerivativeInstrumentsScheduleOfDerivativeInstrumentsMeasuredAtFairValueInStatementOfFinancialPositionDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_351EB6C477E348571CCF26F74423ECE5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_69C12E7F13A2DF2EB09726F74422C9F9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_351EB6C477E348571CCF26F74423ECE5" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_69C12E7F13A2DF2EB09726F74422C9F9" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_DD97FF29C17EBE6F2EC826F74422C77D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_69C12E7F13A2DF2EB09726F74422C9F9" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_DD97FF29C17EBE6F2EC826F74422C77D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BB8C8DB00244218E711626F744228B4B_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_DD97FF29C17EBE6F2EC826F74422C77D" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BB8C8DB00244218E711626F744228B4B_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BB8C8DB00244218E711626F744228B4B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_DD97FF29C17EBE6F2EC826F74422C77D" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BB8C8DB00244218E711626F744228B4B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_667E060007FE497121D026F74422DA46" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_BB8C8DB00244218E711626F744228B4B" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_667E060007FE497121D026F74422DA46" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_E5D11D1B6295D644A08626F74422D91B" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_69C12E7F13A2DF2EB09726F74422C9F9" xlink:to="loc_us-gaap_HedgingDesignationAxis_E5D11D1B6295D644A08626F74422D91B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_1C61F28AD264AEC71F4126F744227515_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_E5D11D1B6295D644A08626F74422D91B" xlink:to="loc_us-gaap_HedgingDesignationDomain_1C61F28AD264AEC71F4126F744227515_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_1C61F28AD264AEC71F4126F744227515" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_E5D11D1B6295D644A08626F74422D91B" xlink:to="loc_us-gaap_HedgingDesignationDomain_1C61F28AD264AEC71F4126F744227515" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_DC0685E88F42D3927E8B26F74422169F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_1C61F28AD264AEC71F4126F744227515" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_DC0685E88F42D3927E8B26F74422169F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_390DD57CF7B51411360126F744224C28" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_1C61F28AD264AEC71F4126F744227515" xlink:to="loc_us-gaap_NondesignatedMember_390DD57CF7B51411360126F744224C28" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_067AF3CD0D883F98F95A26F744228D26" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_69C12E7F13A2DF2EB09726F74422C9F9" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_067AF3CD0D883F98F95A26F744228D26" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_35B91E6A0CC63732DF3726F744222F34_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_067AF3CD0D883F98F95A26F744228D26" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_35B91E6A0CC63732DF3726F744222F34_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_35B91E6A0CC63732DF3726F744222F34" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_067AF3CD0D883F98F95A26F744228D26" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_35B91E6A0CC63732DF3726F744222F34" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CurrencySwapMember" xlink:label="loc_us-gaap_CurrencySwapMember_2F624737C3746C9B59AE26F7442249C3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_35B91E6A0CC63732DF3726F744222F34" xlink:to="loc_us-gaap_CurrencySwapMember_2F624737C3746C9B59AE26F7442249C3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_DB9F7F2114E21BC4C84026F74423CDA5" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_35B91E6A0CC63732DF3726F744222F34" xlink:to="loc_us-gaap_InterestRateSwapMember_DB9F7F2114E21BC4C84026F74423CDA5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ForeignExchangeContractMember" xlink:label="loc_us-gaap_ForeignExchangeContractMember_AB27018B201EC223F0B726F744232C6D" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_35B91E6A0CC63732DF3726F744222F34" xlink:to="loc_us-gaap_ForeignExchangeContractMember_AB27018B201EC223F0B726F744232C6D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_2EFE92623D06FB49536526F74423B2F5" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_69C12E7F13A2DF2EB09726F74422C9F9" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_2EFE92623D06FB49536526F74423B2F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_ED83E4FE164174B47F9526F744231881_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_2EFE92623D06FB49536526F74423B2F5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_ED83E4FE164174B47F9526F744231881_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_ED83E4FE164174B47F9526F744231881" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_2EFE92623D06FB49536526F74423B2F5" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_ED83E4FE164174B47F9526F744231881" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_OtherLongTermAssetsandOtherLongTermLiabilitiesMember" xlink:label="loc_xpo_OtherLongTermAssetsandOtherLongTermLiabilitiesMember_8FF1FDB3E92AD2E69B1A26F744237BAB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ED83E4FE164174B47F9526F744231881" xlink:to="loc_xpo_OtherLongTermAssetsandOtherLongTermLiabilitiesMember_8FF1FDB3E92AD2E69B1A26F744237BAB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherNoncurrentAssetsMember" xlink:label="loc_us-gaap_OtherNoncurrentAssetsMember_3381DE09AC63C631A32926F744233566" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_xpo_OtherLongTermAssetsandOtherLongTermLiabilitiesMember_8FF1FDB3E92AD2E69B1A26F744237BAB" xlink:to="loc_us-gaap_OtherNoncurrentAssetsMember_3381DE09AC63C631A32926F744233566" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherNoncurrentLiabilitiesMember" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_C1B7CD54F5E6A7C56AE426F744238C43" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_xpo_OtherLongTermAssetsandOtherLongTermLiabilitiesMember_8FF1FDB3E92AD2E69B1A26F744237BAB" xlink:to="loc_us-gaap_OtherNoncurrentLiabilitiesMember_C1B7CD54F5E6A7C56AE426F744238C43" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_OtherCurrentAssetsandOtherCurrentLiabilitiesMember" xlink:label="loc_xpo_OtherCurrentAssetsandOtherCurrentLiabilitiesMember_DC3F300D4ADA3694008E26F744239267" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ED83E4FE164174B47F9526F744231881" xlink:to="loc_xpo_OtherCurrentAssetsandOtherCurrentLiabilitiesMember_DC3F300D4ADA3694008E26F744239267" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherCurrentAssetsMember" xlink:label="loc_us-gaap_OtherCurrentAssetsMember_C6F277F0C958047FE64326F74423A1A9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_xpo_OtherCurrentAssetsandOtherCurrentLiabilitiesMember_DC3F300D4ADA3694008E26F744239267" xlink:to="loc_us-gaap_OtherCurrentAssetsMember_C6F277F0C958047FE64326F74423A1A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherCurrentLiabilitiesMember" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_022E0652A495AF022F7C26F74423BD23" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_xpo_OtherCurrentAssetsandOtherCurrentLiabilitiesMember_DC3F300D4ADA3694008E26F744239267" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_022E0652A495AF022F7C26F74423BD23" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_26E7DED6976A7013A35626F744238B88" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_351EB6C477E348571CCF26F74423ECE5" xlink:to="loc_invest_DerivativeNotionalAmount_26E7DED6976A7013A35626F744238B88" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_1CBDB4489D000F24371126F7442345FE" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_351EB6C477E348571CCF26F74423ECE5" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_1CBDB4489D000F24371126F7442345FE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_927435E2289EDD2734B926F74423F275" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_351EB6C477E348571CCF26F74423ECE5" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_927435E2289EDD2734B926F74423F275" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/DerivativeInstrumentsScheduleOfGainsAndLossesRecognizedOnBalanceSheetForDerivativeInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6B71E4997E30AA4432D726F7441CFD99" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_A591B9A274B4E03E3C9726F7441C08DB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6B71E4997E30AA4432D726F7441CFD99" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_A591B9A274B4E03E3C9726F7441C08DB" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_2AD15B9FF762FCD4C84626F7441C710C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_A591B9A274B4E03E3C9726F7441C08DB" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_2AD15B9FF762FCD4C84626F7441C710C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_C85D460FA1131A55C03426F7441CA698_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_2AD15B9FF762FCD4C84626F7441C710C" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_C85D460FA1131A55C03426F7441CA698_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_C85D460FA1131A55C03426F7441CA698" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_2AD15B9FF762FCD4C84626F7441C710C" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_C85D460FA1131A55C03426F7441CA698" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CurrencySwapMember" xlink:label="loc_us-gaap_CurrencySwapMember_BE1C5D1C1B3CF291F8B726F7441CD977" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C85D460FA1131A55C03426F7441CA698" xlink:to="loc_us-gaap_CurrencySwapMember_BE1C5D1C1B3CF291F8B726F7441CD977" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_AD4502CF2EEE006DBB4426F7441CCF5B" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C85D460FA1131A55C03426F7441CA698" xlink:to="loc_us-gaap_InterestRateSwapMember_AD4502CF2EEE006DBB4426F7441CCF5B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ForeignExchangeForwardMember" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_E190BAD48066B1B384CF26F7441C68CB" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C85D460FA1131A55C03426F7441CA698" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_E190BAD48066B1B384CF26F7441C68CB" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_ForeignCurrencyDenominatedNotesMember" xlink:label="loc_xpo_ForeignCurrencyDenominatedNotesMember_4F2D02F3A7B10924A4F126F7441C196E" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_C85D460FA1131A55C03426F7441CA698" xlink:to="loc_xpo_ForeignCurrencyDenominatedNotesMember_4F2D02F3A7B10924A4F126F7441C196E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationAxis" xlink:label="loc_us-gaap_HedgingDesignationAxis_90EB510E34817B1F7C6826F7441CC15B" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_A591B9A274B4E03E3C9726F7441C08DB" xlink:to="loc_us-gaap_HedgingDesignationAxis_90EB510E34817B1F7C6826F7441CC15B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_BE768A2548C754CA830226F7441CBA42_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_90EB510E34817B1F7C6826F7441CC15B" xlink:to="loc_us-gaap_HedgingDesignationDomain_BE768A2548C754CA830226F7441CBA42_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_HedgingDesignationDomain" xlink:label="loc_us-gaap_HedgingDesignationDomain_BE768A2548C754CA830226F7441CBA42" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_90EB510E34817B1F7C6826F7441CC15B" xlink:to="loc_us-gaap_HedgingDesignationDomain_BE768A2548C754CA830226F7441CBA42" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_7C0907F6303FCC849B2326F7441CDC77" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_BE768A2548C754CA830226F7441CBA42" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_7C0907F6303FCC849B2326F7441CDC77" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NondesignatedMember" xlink:label="loc_us-gaap_NondesignatedMember_31F3A3D8A7BFBCC547FB26F7441C76A3" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_BE768A2548C754CA830226F7441CBA42" xlink:to="loc_us-gaap_NondesignatedMember_31F3A3D8A7BFBCC547FB26F7441C76A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet_9CDEB2AFFBFDA5924CEC26F7441C65C2" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6B71E4997E30AA4432D726F7441CFD99" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossRecognizedInOtherComprehensiveIncomeEffectivePortionNet_9CDEB2AFFBFDA5924CEC26F7441C65C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossRecognizedInIncomeIneffectivePortionAndAmountExcludedFromEffectivenessTestingNet" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossRecognizedInIncomeIneffectivePortionAndAmountExcludedFromEffectivenessTestingNet_89A726BA489714003A2426F7441C42C1" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6B71E4997E30AA4432D726F7441CFD99" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossRecognizedInIncomeIneffectivePortionAndAmountExcludedFromEffectivenessTestingNet_89A726BA489714003A2426F7441C42C1" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/DerivativeInstrumentsTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/DocumentAndEntityInformation" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/EarningsPerShare" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/EarningsPerShareScheduleOfEarningsPerShareDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/EarningsPerShareTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/FairValueMeasurements" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/LegalAndRegulatoryMatters" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/LegalAndRegulatoryMattersAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LossContingenciesLineItems" xlink:label="loc_us-gaap_LossContingenciesLineItems_7D64ED6D39B154B99647AA0120502056" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LossContingenciesTable" xlink:label="loc_us-gaap_LossContingenciesTable_77EA1DC44B826327E662AA01205002FA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_7D64ED6D39B154B99647AA0120502056" xlink:to="loc_us-gaap_LossContingenciesTable_77EA1DC44B826327E662AA01205002FA" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LitigationCaseAxis" xlink:label="loc_us-gaap_LitigationCaseAxis_FBBC67341991210B0CC8AA01205008AF" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_77EA1DC44B826327E662AA01205002FA" xlink:to="loc_us-gaap_LitigationCaseAxis_FBBC67341991210B0CC8AA01205008AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LitigationCaseTypeDomain" xlink:label="loc_us-gaap_LitigationCaseTypeDomain_62FF7A9E8E7654CF15E9AA012050D5FC_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LitigationCaseAxis_FBBC67341991210B0CC8AA01205008AF" xlink:to="loc_us-gaap_LitigationCaseTypeDomain_62FF7A9E8E7654CF15E9AA012050D5FC_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LitigationCaseTypeDomain" xlink:label="loc_us-gaap_LitigationCaseTypeDomain_62FF7A9E8E7654CF15E9AA012050D5FC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LitigationCaseAxis_FBBC67341991210B0CC8AA01205008AF" xlink:to="loc_us-gaap_LitigationCaseTypeDomain_62FF7A9E8E7654CF15E9AA012050D5FC" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_CaliforniaLaborCommissionMember" xlink:label="loc_xpo_CaliforniaLaborCommissionMember_633F019DFA60520A515CAA0120501E8B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LitigationCaseTypeDomain_62FF7A9E8E7654CF15E9AA012050D5FC" xlink:to="loc_xpo_CaliforniaLaborCommissionMember_633F019DFA60520A515CAA0120501E8B" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_NumberOfOwnerOperators" xlink:label="loc_xpo_NumberOfOwnerOperators_417F2DE25B126D95721FAA01205001EF" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_7D64ED6D39B154B99647AA0120502056" xlink:to="loc_xpo_NumberOfOwnerOperators_417F2DE25B126D95721FAA01205001EF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LossContingencyNumberOfPlaintiffs" xlink:label="loc_us-gaap_LossContingencyNumberOfPlaintiffs_7CD8C078DC45368A59D9AA0120564F9A" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_7D64ED6D39B154B99647AA0120502056" xlink:to="loc_us-gaap_LossContingencyNumberOfPlaintiffs_7CD8C078DC45368A59D9AA0120564F9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LossContingencyDamagesAwardedValue" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_201D9FF3725997039BC8AA012056101A" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_7D64ED6D39B154B99647AA0120502056" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_201D9FF3725997039BC8AA012056101A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LitigationSettlementAmountAwardedToOtherParty" xlink:label="loc_us-gaap_LitigationSettlementAmountAwardedToOtherParty_4F08B068D965BD4E5B52AA0120565284" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_7D64ED6D39B154B99647AA0120502056" xlink:to="loc_us-gaap_LitigationSettlementAmountAwardedToOtherParty_4F08B068D965BD4E5B52AA0120565284" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_LossContingencyPendingClaimsNumber" xlink:label="loc_us-gaap_LossContingencyPendingClaimsNumber_A21F000137B9DB4BCE7CAA01205682ED" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_7D64ED6D39B154B99647AA0120502056" xlink:to="loc_us-gaap_LossContingencyPendingClaimsNumber_A21F000137B9DB4BCE7CAA01205682ED" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/OrganizationDescriptionOfBusinessAndBasisOfPresentation" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/OrganizationDescriptionOfBusinessAndBasisOfPresentationAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_5779147CA969214B43196E5787132359" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_17361B1BFE78228BF9536E578712A8FD" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_5779147CA969214B43196E5787132359" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_17361B1BFE78228BF9536E578712A8FD" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_F14F8692F91E6F6E76A36E578712A7E9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_17361B1BFE78228BF9536E578712A8FD" xlink:to="loc_us-gaap_StatementScenarioAxis_F14F8692F91E6F6E76A36E578712A7E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_4E0B89F4D71D58A349596E578712491A_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementScenarioAxis_F14F8692F91E6F6E76A36E578712A7E9" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_4E0B89F4D71D58A349596E578712491A_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_4E0B89F4D71D58A349596E578712491A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementScenarioAxis_F14F8692F91E6F6E76A36E578712A7E9" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_4E0B89F4D71D58A349596E578712491A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ProFormaMember" xlink:label="loc_us-gaap_ProFormaMember_54C6BE4B7029B9EEE16A6E578713962D" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_4E0B89F4D71D58A349596E578712491A" xlink:to="loc_us-gaap_ProFormaMember_54C6BE4B7029B9EEE16A6E578713962D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_752459624429C2CA92636E578713FCA1" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_17361B1BFE78228BF9536E578712A8FD" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_752459624429C2CA92636E578713FCA1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_3412A13BDD3686A0CEA86E578713FD68_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_752459624429C2CA92636E578713FCA1" xlink:to="loc_us-gaap_TypeOfAdoptionMember_3412A13BDD3686A0CEA86E578713FD68_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_3412A13BDD3686A0CEA86E578713FD68" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_752459624429C2CA92636E578713FCA1" xlink:to="loc_us-gaap_TypeOfAdoptionMember_3412A13BDD3686A0CEA86E578713FD68" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_AccountingStandardsUpdate201707Member" xlink:label="loc_xpo_AccountingStandardsUpdate201707Member_3A88B96F78DE1995E1FA6E578713CC79" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_3412A13BDD3686A0CEA86E578713FD68" xlink:to="loc_xpo_AccountingStandardsUpdate201707Member_3A88B96F78DE1995E1FA6E578713CC79" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_884F1A3DD2C226899A746E5787131373" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_5779147CA969214B43196E5787132359" xlink:to="loc_us-gaap_NumberOfReportableSegments_884F1A3DD2C226899A746E5787131373" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_EffectiveIncomeTaxRateReconciliationSharebasedCompensationExcessTaxBenefitAmount" xlink:label="loc_xpo_EffectiveIncomeTaxRateReconciliationSharebasedCompensationExcessTaxBenefitAmount_0D31FF6C4538EBB5D71C6E57871359FC" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_5779147CA969214B43196E5787132359" xlink:to="loc_xpo_EffectiveIncomeTaxRateReconciliationSharebasedCompensationExcessTaxBenefitAmount_0D31FF6C4538EBB5D71C6E57871359FC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_5196AB9767E38782EEE96E578713FB9B" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_5779147CA969214B43196E5787132359" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_5196AB9767E38782EEE96E578713FB9B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_38F94EB0B9A6C93F79DA6E578713B8DE" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_5779147CA969214B43196E5787132359" xlink:to="loc_us-gaap_OperatingExpenses_38F94EB0B9A6C93F79DA6E578713B8DE" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/OrganizationDescriptionOfBusinessAndBasisOfPresentationPolicies" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/RestructuringCharges" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/RestructuringChargesSummaryOfRestructuringReserveDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestructuringCostAndReserveLineItems" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_94AAFE3265FABCE4C42226F7442ED7B4" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_86485A975CEC2F78BFEA26F7442D81E8" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_94AAFE3265FABCE4C42226F7442ED7B4" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_86485A975CEC2F78BFEA26F7442D81E8" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_4FED09C3891DB97A7BA426F7442D3DCC" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_86485A975CEC2F78BFEA26F7442D81E8" xlink:to="loc_us-gaap_ConsolidationItemsAxis_4FED09C3891DB97A7BA426F7442D3DCC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_06FA8621A854A022705626F7442D1BF7_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConsolidationItemsAxis_4FED09C3891DB97A7BA426F7442D3DCC" xlink:to="loc_us-gaap_ConsolidationItemsDomain_06FA8621A854A022705626F7442D1BF7_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_06FA8621A854A022705626F7442D1BF7" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConsolidationItemsAxis_4FED09C3891DB97A7BA426F7442D3DCC" xlink:to="loc_us-gaap_ConsolidationItemsDomain_06FA8621A854A022705626F7442D1BF7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:label="loc_us-gaap_OperatingSegmentsMember_77B0907FAF1D74285B5526F7442D0EA5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_06FA8621A854A022705626F7442D1BF7" xlink:to="loc_us-gaap_OperatingSegmentsMember_77B0907FAF1D74285B5526F7442D0EA5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:label="loc_us-gaap_CorporateNonSegmentMember_1C306EC2B3EEDCD3B5D026F7442DECC2" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_06FA8621A854A022705626F7442D1BF7" xlink:to="loc_us-gaap_CorporateNonSegmentMember_1C306EC2B3EEDCD3B5D026F7442DECC2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_4B6E0B98D82CB1496CDC26F7442E4DEF" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_86485A975CEC2F78BFEA26F7442D81E8" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_4B6E0B98D82CB1496CDC26F7442E4DEF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_A2A247AA7665A0A0CF5826F7442EFEDA_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_4B6E0B98D82CB1496CDC26F7442E4DEF" xlink:to="loc_us-gaap_SegmentDomain_A2A247AA7665A0A0CF5826F7442EFEDA_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_A2A247AA7665A0A0CF5826F7442EFEDA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_4B6E0B98D82CB1496CDC26F7442E4DEF" xlink:to="loc_us-gaap_SegmentDomain_A2A247AA7665A0A0CF5826F7442EFEDA" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_TransportationMember" xlink:label="loc_xpo_TransportationMember_0FDA373E747EC80644CE26F7442EC6C3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_A2A247AA7665A0A0CF5826F7442EFEDA" xlink:to="loc_xpo_TransportationMember_0FDA373E747EC80644CE26F7442EC6C3" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_ContractLogisticsMember" xlink:label="loc_xpo_ContractLogisticsMember_9586B23A2DB5E019193C26F7442EF4BA" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_A2A247AA7665A0A0CF5826F7442EFEDA" xlink:to="loc_xpo_ContractLogisticsMember_9586B23A2DB5E019193C26F7442EF4BA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestructuringCostAndReserveAxis" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_D7060DA3CD9762188D4D26F7442EA869" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_86485A975CEC2F78BFEA26F7442D81E8" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_D7060DA3CD9762188D4D26F7442EA869" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_C2B61537F063249B00AE26F7442E2094_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_D7060DA3CD9762188D4D26F7442EA869" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_C2B61537F063249B00AE26F7442E2094_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_TypeOfRestructuringDomain" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_C2B61537F063249B00AE26F7442E2094" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_D7060DA3CD9762188D4D26F7442EA869" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_C2B61537F063249B00AE26F7442E2094" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_FacilityClosingMember" xlink:label="loc_us-gaap_FacilityClosingMember_AD812F14606D78ADB25B26F7442EF09C" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_C2B61537F063249B00AE26F7442E2094" xlink:to="loc_us-gaap_FacilityClosingMember_AD812F14606D78ADB25B26F7442EF09C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EmployeeSeveranceMember" xlink:label="loc_us-gaap_EmployeeSeveranceMember_1C29DDBFC2785F379B4026F7442E6B48" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_C2B61537F063249B00AE26F7442E2094" xlink:to="loc_us-gaap_EmployeeSeveranceMember_1C29DDBFC2785F379B4026F7442E6B48" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ContractTerminationMember" xlink:label="loc_us-gaap_ContractTerminationMember_C3CB74ED2DD4D5DA31A626F7442E8C15" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_C2B61537F063249B00AE26F7442E2094" xlink:to="loc_us-gaap_ContractTerminationMember_C3CB74ED2DD4D5DA31A626F7442E8C15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestructuringReserveRollForward" xlink:label="loc_us-gaap_RestructuringReserveRollForward_0AA66790F7ACA4D9D7CA26F7442E0424" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_94AAFE3265FABCE4C42226F7442ED7B4" xlink:to="loc_us-gaap_RestructuringReserveRollForward_0AA66790F7ACA4D9D7CA26F7442E0424" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestructuringReserve" xlink:label="loc_us-gaap_RestructuringReserve_5D4E80C1CF575F52FEE926F7442E95B3" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_0AA66790F7ACA4D9D7CA26F7442E0424" xlink:to="loc_us-gaap_RestructuringReserve_5D4E80C1CF575F52FEE926F7442E95B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RestructuringCharges" xlink:label="loc_us-gaap_RestructuringCharges_42E36DED255270D9E02F26F7442FF75B" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_0AA66790F7ACA4D9D7CA26F7442E0424" xlink:to="loc_us-gaap_RestructuringCharges_42E36DED255270D9E02F26F7442FF75B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_PaymentsForRestructuring" xlink:label="loc_us-gaap_PaymentsForRestructuring_A0E28A8DCE5B6344E7F226F7442FC002" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_0AA66790F7ACA4D9D7CA26F7442E0424" xlink:to="loc_us-gaap_PaymentsForRestructuring_A0E28A8DCE5B6344E7F226F7442FC002" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OtherRestructuringCosts" xlink:label="loc_us-gaap_OtherRestructuringCosts_49B4A818A76D7ED62D5026F7442F80B3" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_0AA66790F7ACA4D9D7CA26F7442E0424" xlink:to="loc_us-gaap_OtherRestructuringCosts_49B4A818A76D7ED62D5026F7442F80B3" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/RestructuringChargesTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/SegmentReporting" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/SegmentReportingAdditionalInformationDetails" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/SegmentReportingSelectedFinancialDataForEachOfOperatingSegmentsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentReportingInformationLineItems" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_469518799A558B9BBDCBAA012041C8DE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_8FE95E0CA2D41161AB78AA01204082E5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_469518799A558B9BBDCBAA012041C8DE" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_8FE95E0CA2D41161AB78AA01204082E5" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsAxis" xlink:label="loc_us-gaap_ConsolidationItemsAxis_3759AC14B06C47191BA4AA0120403BD9" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_8FE95E0CA2D41161AB78AA01204082E5" xlink:to="loc_us-gaap_ConsolidationItemsAxis_3759AC14B06C47191BA4AA0120403BD9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_1CAC70C6638127EA2FABAA0120401D1B_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConsolidationItemsAxis_3759AC14B06C47191BA4AA0120403BD9" xlink:to="loc_us-gaap_ConsolidationItemsDomain_1CAC70C6638127EA2FABAA0120401D1B_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ConsolidationItemsDomain" xlink:label="loc_us-gaap_ConsolidationItemsDomain_1CAC70C6638127EA2FABAA0120401D1B" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConsolidationItemsAxis_3759AC14B06C47191BA4AA0120403BD9" xlink:to="loc_us-gaap_ConsolidationItemsDomain_1CAC70C6638127EA2FABAA0120401D1B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingSegmentsMember" xlink:label="loc_us-gaap_OperatingSegmentsMember_9975FB69CF435285F170AA012040B8EE" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_1CAC70C6638127EA2FABAA0120401D1B" xlink:to="loc_us-gaap_OperatingSegmentsMember_9975FB69CF435285F170AA012040B8EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CorporateNonSegmentMember" xlink:label="loc_us-gaap_CorporateNonSegmentMember_37A7EBD8B74EEBEBBF90AA0120418535" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_1CAC70C6638127EA2FABAA0120401D1B" xlink:to="loc_us-gaap_CorporateNonSegmentMember_37A7EBD8B74EEBEBBF90AA0120418535" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_IntersegmentEliminationMember" xlink:label="loc_us-gaap_IntersegmentEliminationMember_EAF568CFC93E28667910AA01204198C6" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConsolidationItemsDomain_1CAC70C6638127EA2FABAA0120401D1B" xlink:to="loc_us-gaap_IntersegmentEliminationMember_EAF568CFC93E28667910AA01204198C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_25113D0054C1E9746C23AA012041CC01" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_8FE95E0CA2D41161AB78AA01204082E5" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_25113D0054C1E9746C23AA012041CC01" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_EC70730CEAFA4FE4C1ADAA012041EB66_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_25113D0054C1E9746C23AA012041CC01" xlink:to="loc_us-gaap_SegmentDomain_EC70730CEAFA4FE4C1ADAA012041EB66_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SegmentDomain" xlink:label="loc_us-gaap_SegmentDomain_EC70730CEAFA4FE4C1ADAA012041EB66" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_25113D0054C1E9746C23AA012041CC01" xlink:to="loc_us-gaap_SegmentDomain_EC70730CEAFA4FE4C1ADAA012041EB66" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_TransportationMember" xlink:label="loc_xpo_TransportationMember_45CCD5F36B65DD39AADEAA0120413BB4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_EC70730CEAFA4FE4C1ADAA012041EB66" xlink:to="loc_xpo_TransportationMember_45CCD5F36B65DD39AADEAA0120413BB4" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_ContractLogisticsMember" xlink:label="loc_xpo_ContractLogisticsMember_490B6F93B11E353CBCFFAA012041226F" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_EC70730CEAFA4FE4C1ADAA012041EB66" xlink:to="loc_xpo_ContractLogisticsMember_490B6F93B11E353CBCFFAA012041226F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_5F38133C786064C5F835AA012041006E" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_469518799A558B9BBDCBAA012041C8DE" xlink:to="loc_us-gaap_Revenues_5F38133C786064C5F835AA012041006E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_1D1A82828095C29F43AFAA0120419655" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_469518799A558B9BBDCBAA012041C8DE" xlink:to="loc_us-gaap_OperatingIncomeLoss_1D1A82828095C29F43AFAA0120419655" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_DepreciationAndAmortization" xlink:label="loc_us-gaap_DepreciationAndAmortization_66A3F0D478B3C220AB2CAA012042F794" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_469518799A558B9BBDCBAA012041C8DE" xlink:to="loc_us-gaap_DepreciationAndAmortization_66A3F0D478B3C220AB2CAA012042F794" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/SegmentReportingTables" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/StockholdersEquity" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/StockholdersEquityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_6AC237E6CC8ED69585808D065B315B74" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_AA5E2DF9FE83040B599D8D065B2C51AB" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_6AC237E6CC8ED69585808D065B315B74" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_AA5E2DF9FE83040B599D8D065B2C51AB" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_D75D9B6A366E72B8914E8D065B2CCF0A" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_AA5E2DF9FE83040B599D8D065B2C51AB" xlink:to="loc_us-gaap_CounterpartyNameAxis_D75D9B6A366E72B8914E8D065B2CCF0A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_F62340E51F106429E8CA8D065B2CB950_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CounterpartyNameAxis_D75D9B6A366E72B8914E8D065B2CCF0A" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_F62340E51F106429E8CA8D065B2CB950_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_F62340E51F106429E8CA8D065B2CB950" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CounterpartyNameAxis_D75D9B6A366E72B8914E8D065B2CCF0A" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_F62340E51F106429E8CA8D065B2CB950" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_JPMorganChaseBankNationalAssociationLondonBranchMember" xlink:label="loc_xpo_JPMorganChaseBankNationalAssociationLondonBranchMember_15D65C26E0007AFB51E78D065B2D01D0" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_F62340E51F106429E8CA8D065B2CB950" xlink:to="loc_xpo_JPMorganChaseBankNationalAssociationLondonBranchMember_15D65C26E0007AFB51E78D065B2D01D0" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_MorganStanleyCo.LLCMember" xlink:label="loc_xpo_MorganStanleyCo.LLCMember_D82EEE13C2F046E7E2EE8D065B2EC769" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_F62340E51F106429E8CA8D065B2CB950" xlink:to="loc_xpo_MorganStanleyCo.LLCMember_D82EEE13C2F046E7E2EE8D065B2EC769" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_C8502B89602D2B8B77468D065B2FD851" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_AA5E2DF9FE83040B599D8D065B2C51AB" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_C8502B89602D2B8B77468D065B2FD851" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_9751B363EF36956965E88D065B2F9F8F_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_C8502B89602D2B8B77468D065B2FD851" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_9751B363EF36956965E88D065B2F9F8F_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_9751B363EF36956965E88D065B2F9F8F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_C8502B89602D2B8B77468D065B2FD851" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_9751B363EF36956965E88D065B2F9F8F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OverAllotmentOptionMember" xlink:label="loc_us-gaap_OverAllotmentOptionMember_C828FB39DA27F8087FAD8D065B302F26" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_9751B363EF36956965E88D065B2F9F8F" xlink:to="loc_us-gaap_OverAllotmentOptionMember_C828FB39DA27F8087FAD8D065B302F26" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_OfferedDirectlyByTheCompanyMember" xlink:label="loc_xpo_OfferedDirectlyByTheCompanyMember_6422955C5FCE8DBD69508D065B309FD6" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_9751B363EF36956965E88D065B2F9F8F" xlink:to="loc_xpo_OfferedDirectlyByTheCompanyMember_6422955C5FCE8DBD69508D065B309FD6" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_OfferedInConnectionWithForwardSaleAgreementsMember" xlink:label="loc_xpo_OfferedInConnectionWithForwardSaleAgreementsMember_2DA5054B7240E6E2D45B8D065B31C6FF" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_9751B363EF36956965E88D065B2F9F8F" xlink:to="loc_xpo_OfferedInConnectionWithForwardSaleAgreementsMember_2DA5054B7240E6E2D45B8D065B31C6FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_7A33B1DA7745A2C425818D065B323428" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6AC237E6CC8ED69585808D065B315B74" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_7A33B1DA7745A2C425818D065B323428" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockPricePerShare" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_3700626E5368E2D58B248D065B32AD83" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6AC237E6CC8ED69585808D065B315B74" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_3700626E5368E2D58B248D065B32AD83" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_SaleofStockForwardSaleAgreementExpectedClosingPeriodAfterStockOffering" xlink:label="loc_xpo_SaleofStockForwardSaleAgreementExpectedClosingPeriodAfterStockOffering_20272F974A5108DF5AB38D065B32E8A2" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6AC237E6CC8ED69585808D065B315B74" xlink:to="loc_xpo_SaleofStockForwardSaleAgreementExpectedClosingPeriodAfterStockOffering_20272F974A5108DF5AB38D065B32E8A2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedPerTransaction" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedPerTransaction_0A332338C5B52D52FAF38D065B323B9F" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6AC237E6CC8ED69585808D065B315B74" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedPerTransaction_0A332338C5B52D52FAF38D065B323B9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_96B2D97DF6F120BDDF278D065B320BD8" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_6AC237E6CC8ED69585808D065B315B74" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_96B2D97DF6F120BDDF278D065B320BD8" xlink:type="arc" />
  </link:definitionLink>
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/SubsequentEvents" xlink:type="extended" />
  <link:definitionLink xlink:role="http://www.xpologistics.com/role/SubsequentEventsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventLineItems" xlink:label="loc_us-gaap_SubsequentEventLineItems_E1BC1833A53640D18EFE8D065B077A52" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventTable" xlink:label="loc_us-gaap_SubsequentEventTable_FDAC4737B7048FFF41F88D065B0186E5" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_E1BC1833A53640D18EFE8D065B077A52" xlink:to="loc_us-gaap_SubsequentEventTable_FDAC4737B7048FFF41F88D065B0186E5" xlink:type="arc" xbrldt:closed="true" xbrldt:contextElement="segment" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_82A8356AE6CCBC8327F78D0F38887B83" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_FDAC4737B7048FFF41F88D065B0186E5" xlink:to="loc_us-gaap_CounterpartyNameAxis_82A8356AE6CCBC8327F78D0F38887B83" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_22446403B86C487F04548D0F388A4F45_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CounterpartyNameAxis_82A8356AE6CCBC8327F78D0F38887B83" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_22446403B86C487F04548D0F388A4F45_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_22446403B86C487F04548D0F388A4F45" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CounterpartyNameAxis_82A8356AE6CCBC8327F78D0F38887B83" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_22446403B86C487F04548D0F388A4F45" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_XPOCollectionsDesignatedActivityCompanyLimitedMember" xlink:label="loc_xpo_XPOCollectionsDesignatedActivityCompanyLimitedMember_E106AEE7FDEE93A301498D0F74419DA0" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_22446403B86C487F04548D0F388A4F45" xlink:to="loc_xpo_XPOCollectionsDesignatedActivityCompanyLimitedMember_E106AEE7FDEE93A301498D0F74419DA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_03A4F05D4BBB950A0F098D0E1E3C916B" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_FDAC4737B7048FFF41F88D065B0186E5" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_03A4F05D4BBB950A0F098D0E1E3C916B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_6D671487A4863DBC5EFE8D0E1E5C78B0_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_03A4F05D4BBB950A0F098D0E1E3C916B" xlink:to="loc_us-gaap_RelatedPartyDomain_6D671487A4863DBC5EFE8D0E1E5C78B0_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyDomain" xlink:label="loc_us-gaap_RelatedPartyDomain_6D671487A4863DBC5EFE8D0E1E5C78B0" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_03A4F05D4BBB950A0F098D0E1E3C916B" xlink:to="loc_us-gaap_RelatedPartyDomain_6D671487A4863DBC5EFE8D0E1E5C78B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_AffiliatedEntityMember" xlink:label="loc_us-gaap_AffiliatedEntityMember_30A95A57ED4538C036088D0ED58840CA" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_6D671487A4863DBC5EFE8D0E1E5C78B0" xlink:to="loc_us-gaap_AffiliatedEntityMember_30A95A57ED4538C036088D0ED58840CA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_3D7446BCF90849B5A5FF8D065B023B81" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_FDAC4737B7048FFF41F88D065B0186E5" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_3D7446BCF90849B5A5FF8D065B023B81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_5BEF979540C34DB6F3F48D065B025769_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_3D7446BCF90849B5A5FF8D065B023B81" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_5BEF979540C34DB6F3F48D065B025769_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_5BEF979540C34DB6F3F48D065B025769" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_3D7446BCF90849B5A5FF8D065B023B81" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_5BEF979540C34DB6F3F48D065B025769" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_EuropeanTradeReceivablesSecuritizationProgramMember" xlink:label="loc_xpo_EuropeanTradeReceivablesSecuritizationProgramMember_CA2019E51AE406E5F7BB8D065B0251B4" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_5BEF979540C34DB6F3F48D065B025769" xlink:to="loc_xpo_EuropeanTradeReceivablesSecuritizationProgramMember_CA2019E51AE406E5F7BB8D065B0251B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OwnershipAxis" xlink:label="loc_us-gaap_OwnershipAxis_75D58376566FB319DAA98D065B042098" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_FDAC4737B7048FFF41F88D065B0186E5" xlink:to="loc_us-gaap_OwnershipAxis_75D58376566FB319DAA98D065B042098" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OwnershipDomain" xlink:label="loc_us-gaap_OwnershipDomain_68F89E808EEAD134329F8D065B04F278_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_OwnershipAxis_75D58376566FB319DAA98D065B042098" xlink:to="loc_us-gaap_OwnershipDomain_68F89E808EEAD134329F8D065B04F278_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_OwnershipDomain" xlink:label="loc_us-gaap_OwnershipDomain_68F89E808EEAD134329F8D065B04F278" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_OwnershipAxis_75D58376566FB319DAA98D065B042098" xlink:to="loc_us-gaap_OwnershipDomain_68F89E808EEAD134329F8D065B04F278" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_XPOLogisticsEuropeSAMember" xlink:label="loc_xpo_XPOLogisticsEuropeSAMember_0EFF35EC605C543356F78D08E1914065" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OwnershipDomain_68F89E808EEAD134329F8D065B04F278" xlink:to="loc_xpo_XPOLogisticsEuropeSAMember_0EFF35EC605C543356F78D08E1914065" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_E9744703EC89E72209848D065B06DCB3" xlink:type="locator" />
    <link:definitionArc order="5" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_FDAC4737B7048FFF41F88D065B0186E5" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_E9744703EC89E72209848D065B06DCB3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_6C351E7F76AC089FF4158D065B06E14F_default" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_E9744703EC89E72209848D065B06DCB3" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_6C351E7F76AC089FF4158D065B06E14F_default" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_6C351E7F76AC089FF4158D065B06E14F" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_E9744703EC89E72209848D065B06DCB3" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_6C351E7F76AC089FF4158D065B06E14F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_772F1A7E2D30E57EAE0C8D065B071802" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_6C351E7F76AC089FF4158D065B06E14F" xlink:to="loc_us-gaap_SubsequentEventMember_772F1A7E2D30E57EAE0C8D065B071802" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2017/elts/us-gaap-2017-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_BBE9DCF70A4CE69526D98D065B07CF32" xlink:type="locator" />
    <link:definitionArc order="1" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_E1BC1833A53640D18EFE8D065B077A52" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_BBE9DCF70A4CE69526D98D065B07CF32" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_TransferOfFinancialAssetsAmountEligibleToBeTransfered" xlink:label="loc_xpo_TransferOfFinancialAssetsAmountEligibleToBeTransfered_ED9BAA70BAA731B405C68D065B076937" xlink:type="locator" />
    <link:definitionArc order="2" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_E1BC1833A53640D18EFE8D065B077A52" xlink:to="loc_xpo_TransferOfFinancialAssetsAmountEligibleToBeTransfered_ED9BAA70BAA731B405C68D065B076937" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_TransferOfFinancialAssetsAgreementTerm" xlink:label="loc_xpo_TransferOfFinancialAssetsAgreementTerm_ACC17BDC77DA64DF23A08D065B074022" xlink:type="locator" />
    <link:definitionArc order="3" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_E1BC1833A53640D18EFE8D065B077A52" xlink:to="loc_xpo_TransferOfFinancialAssetsAgreementTerm_ACC17BDC77DA64DF23A08D065B074022" xlink:type="arc" />
    <link:loc xlink:href="xpo-20170930.xsd#xpo_TransferOfFinancialAssetsAgreementInterestRate" xlink:label="loc_xpo_TransferOfFinancialAssetsAgreementInterestRate_B1BD2B62729089B39A728D065B0722E9" xlink:type="locator" />
    <link:definitionArc order="4" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_E1BC1833A53640D18EFE8D065B077A52" xlink:to="loc_xpo_TransferOfFinancialAssetsAgreementInterestRate_B1BD2B62729089B39A728D065B0722E9" xlink:type="arc" />
  </link:definitionLink>
</link:linkbase>
